What is it?
An expert opinion service provides independent, science-based interpretation of existing data and studies to assess chemical safety, regulatory relevance, and uncertainty.
What we offer
We provide expert opinion services that deliver independent, science-based evaluations of chemicals with regulatory relevance and data gaps, helping clients interpret complex hazard and risk data on their chemicals, support decision-making, and strengthen technical or regulatory positions.
A core area of our expertise is weight-of-evidence approaches under REACH to minimise animal testing, using expert judgement to determine when additional studies may not be scientifically necessary.
- Support regulatory submission and internal decision-making.
- Reducing uncertainty and avoiding overly conservative assumptions.
- Helping prioritise further studies if necessary.
- Support for reclassification
- Guidance on exposure limits and risk management
- Strategic input on substitution option
Yordas multidisciplinary team of chemists, toxicologists, exposure modellers, and environmental scientists will make sure that:
Data are integrated across studies
Adversity thresholds are clearly defined
Toxicological conclusions are aligned with regulatory intent
Strategies are defended to regulators
Expert consultants
The use of expert judgement is essential to establish and justify a sound assessment and to conclude on an endpoint based on the available evidence.
Client focused delivery
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Our Process
Yordas brings years of expertise under REACH and other regulatory frameworks, lead registrations and dossier/substance evaluations with numerous endpoint data in a weight of evidence approach.
Data Review
We review all available client-provided data on a chemical and address the specific questions posed—most commonly relating to classification status, potential reclassification, exposure limits, or suitability for substitution.
Among existing data, there may be existing studies, published and unpublished literature, human data and data from higher-tier studies that often could be used to fulfil endpoints for low-tier endpoints.
Weight of Evidence Approach
In addition to a combination of existing studies from several sources, read-across data and QSARs can also be used as part of the weight of evidence approach; in general, the assessment for the endpoint is stronger and more robust if a high number of evidence are included.
Assessment
Once the data have been gathered, they need to be assessed for relevance and reliability in relation to a particular endpoint.